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Overall Health

Kelulut Honey Stingless bee honey contains up to ten times more antioxidants than regular honey and is twice as nutritious.

Kelulut Honey  has 5 times more antioxidant activity (5-fold higher) than New Zealand Manuka Honey.

Kelulut Honey  has higher antioxidant properties (total phenolic and flavonoid content) than Manuka Honey.

CONCLUSION  To the best of our knowledge, this work is the first report to determine the antioxidant activity of Kelulut Honey and its effect on the viability of Lymphoblastoid Cell Line (LCL) .

Kelulut Honey  supplementation increases lymphoblastic cell viability by more than 150%

Kelulut Honey  is a potent antioxidant that has high total phenolic content, total flavonoid content, and Ferric Reducing Antioxidant Potential (FRAP) which may contribute to oxidative damage protection.

 

Asthma

Allergic asthma is a chronic inflammatory disorder of the pulmonary airways. Gelam Honey has been proven to possess anti-inflammatory property with great potential to treat an inflammatory condition. 

 

Anti-Aging

Honey can help stop wrinkles from forming, keep the skin looking young, and prevent infections on the skin that can accelerate aging. Toxins sink into your skin everyday and cause aging to happen more quickly, but honey can reverse it. Honey uses its exfoliating and healing powers when you make an anti-aging face mask to reduce the appearance and speed of aging. 

Kelulut Honey is a good source of natural antioxidant which potentially delays skin aging. Stingless bee honey (Kelulut Honey) beneficially increases collagen and decreases the signs of aging skin.  

 

Blood Pressure /Hypertension

Kelulut Honey  has stronger antioxidant properties compared to other honey types and may be a functional food against Metabolic Syndrome (a group of conditions including central obesity, hyperglycemia, dyslipidemia, and hypertension that increases the risk for cardiometabolic diseases) induced by a High-Carbohydrate High-Fat diet. 

 

Brain / Memory

Tualang Honey every day for 28 days mitigated the impact of noise stress on the brain. It improved memory, decreased oxidative stress, increased the survival of nerve cells, decreased acetylcholinesterase, and enhanced neuronal proliferation in certain areas of the brain, meaning it protected against memory decline. 

In a study on postmenopausal women, 20 mg/day (< 1/16 tsp) of Tualang Honey led to an improvement in immediate memory, and performance was comparable to receiving estrogen and progestin therapy. 

 

Cancer

Tualang Honey and Manuka Honey exhibit anti-breast cancer activity and could synergize with or be a substitute for chemotherapeutic drugs given at suboptimal doses for cancer therapy. 

The combination of Tualang Honey and Tamoxifen (a drug used to treat breast cancer) is more potent than either agent alone in inhibiting cell growth of both ER𝛼-positive and ER𝛼-negative breast cancer cells via direct induction of apoptosis (a type of cell death in which a series of molecular steps in a cell lead to its death).

Tualang Honey and Manuka honeys exhibit antibreast cancer activity. (NOTE: Tualang Honey is better than Manuka Honey as Tualang Honey outperformed Manuka in every test.) Tualang Honey could synergize with or be a substitute for chemotherapeutic drugs for cancer therapy.

Kelulut Honey has chemopreventive properties. 

Gelam Honey showed an effect to prevent, stop, and kill cancer cells in Breast Cancer / Colorectal Cancer / Liver Cancer / Lung Cancer. 

Gelam Honey and Ginger Extract stop the spread, as well as cause the death of a colorectal cancer cell line. Moreover they displayed synergism in anti-proliferative activity against colon cancer cells when combined.  

Despite honey's many reported anti-cancer activities, very few clinical studies have been undertaken. 

Gelam Honey acts as a radioprotectant agent against exposure to high levels of radiation from cosmic rays, nuclear reactor plants, X-rays, CT scans, and radiotherapy which can result in long-term health effects such as cancer and cardiovascular disease. 

Tualang Honey improved cancer-related fatigue and quality of life of patients with head and neck cancer post-chemotherapy or radiotherapy. 

Cancer related fatigue (CRF) is a problem experienced by head and neck cancer patients, especially those who undergo chemoradiation therapy. CRF may persist for years post chemoradiation therapy and significantly impair their quality of life (QOL). Tualang Honey is rich in amino acids, vitamins, minerals and enzymes. It is proven to have anti-inflammatory, antioxidant and anti-tumour properties. As Cancer Related Fatigue is related to inflammatory mediators, the effects of Tualang Honey may improve CRF.

Tualang Honey showed antiproliferative effect (stops the growth of cancer) on oral squamous cell carcinomas (OSCC) and human osteosarcoma (HOS) cell lines by inducing early apoptosis (cell death). Simply put, Tualang Honey helps stop and kill cancer.

Usage is three times a day after three meals. After oral care is required before use, use 10 grams of honey, circulate in the oral cavity for at least 30 seconds, and slowly swallow. Do not eat, drink, or gargle within 30 minutes of use.

Gelam honey was reported to exhibit anti-oxidative, anti-tumour and anti-inflammatory properties against many types of cancer. The main aim of the present study was to evaluate the effect of Gelam honey on the oxidative stress level of human lung cancer cells. Gelam honey reduces lipid peroxidation but not protein oxidation in human lung cancer cells subjected to oxidative stress.

Conclusions: Honey is a natural product that shows potential effects to inhibit or suppress the development and progression of tumor and cancer. Its antiproliferative, antitumor, antimetastic and anticancer effects are mediated via diverse mechanisms, including cell cycle arrest, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling, and inhibition of angiogenesis in cancer cells. Honey is highly and selectively cytotoxic against tumor or cancer cells while it is non-cytotoxic to normal cells. It can inhibit cancerogenesis by modulating or interfering with the molecular processes or events of initiation, promotion, and progression stages. It, therefore, can be considered a potential and promising anticancer agent which warrants further research—both in experimental and clinical studies.

A study that investigated the antiproliferative effects of Gelam Honey on HepG2 found that the IC50 value of Gelam Honey towards HepG2 was 25% whereas it was 70% for normal human hepatocytes (WRL-68) [50]. This shows Gelam Honey is selectively cytototoxic to liver cancer cells. The study also revealed that Gelam Honey inhibited the proliferation of HepG2 cells and induced apoptosis in HepG2. A similar study evaluated the antiproliferative effect of a mixture of Gelam Honey and Tinospora crispa on HepG2 and WRL-68 cells [51]. The study reported an IC50 value of 42.67% in HepG2 cells and none in the WRL-68 cells. The mixture was also found to induce apoptosis in HepG2 cells.

  • ANTI-CANCER PROPERTIES OF MALAYSIAN TUALANG HONEY

Malaysian Tualang Honey (MTH) may have the potential as a natural cancer ‘killer’ due multi-biological activities. The possible anti-cancer activities of Tualang Honey seem to have involved multiple mechanisms for instance, through apoptotic, antiproliferative, anti-oxidant and anti-inflammatory pathways. Studies have been performed to test MTH against difference cancer cell lines. It was first reported that Malaysian Tualang Honey is capable of inducing apoptosis in human breast cancer cell line (MCF-7). The apoptotic effect was associated with depolarization of the mitochondrial membrane in the MCF-7 cell line. Mitochondria serve as an energy (ATP) generator and metabolites for the building of macromolecules and reactive oxygen species (ROS). This process is vital in cell viability and proliferation. However, mitochondrial dysfunction has been reported in cancer cells, which cause major changes in cellular energy metabolism and excessive production of ROS. This will affect cell fates and drug responses. Data have shown that Malaysian Tualang Honey affects mitochondrial membrane of the MCF-7 cell line, hence providing another adjunct treatment in cancer therapy to kill cancer cell.

 

 

Cardiovascular / Heart Disease

    Tualang Honey has antioxidant properties that improve oxidative stress status in chronic smokers and play a beneficial role in reducing the risk of cardiovascular diseases that have been linked to cigarette smoking.

    Tualang Honey can be used by those who are exposed to cigarette smoke either as active or passive smokers in order to protect or reduce the risk of having cardiovascular diseases.

    Kelulut Honey has stronger antioxidant properties compared to other honey types and may be a functional food against Metabolic Syndrome (a group of conditions including central obesity, hyperglycemia, dyslipidemia, and hypertension that increases the risk for cardiometabolic diseases) induced by a High-Carbohydrate High-Fat diet. 

    Studies demonstrate the potential for Tualang Honey to be cardioprotective. 

    Treatment of Tualang Honey reverses ISO-induced heart enlargement, elevation of cardiac troponin, cardiac enzymes, serum total cholesterol, and triglyceride, as well as decreased antioxidant activity.

    Conclusion: Subjects (postmenopausal women aged 45-65 years) who received Tualang Honey  supplementation showed superior effect in lowering diastolic blood pressure and fasting blood sugar compared to Honey Cocktail (mixture of honey, bee bread, and royal jelly). 

    Colon 

    Conclusion: The combined treatment of Gelam honey and ginger extract could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.

     

    COPD

    Supplementation of Tualang Honey in patients with COPD results in better intermediate and long term changes in the overall quality of life.  

     

    Coughs

    The result of the study demonstrated that receiving a 2.5-mL (1/2 teaspoon) dose of honey before sleep has a more alleviating effect on upper respiratory tract infection (URIs)-induced cough compared with dextromethorphan (DM) found in cough medicine,  and diphenhydramine (DPH) found in antihistamines, doses.

     

    COVID

    Products of honey bees that contain mixtures of potentially active chemicals, possess unique properties that might help to protect, fight, and alleviate symptoms of COVID-19 infection.

     

    Depression

    Tualang Honey has antidepressant-like effects. It decreases depression in subjects exposed to stress and reduces depressive-like behavior via preventing hypersecretion of glucocorticoids and improving brain oxidative status.

    Supplementation with Tualang Honey seems to mediate the antidepressant-like effects as it improves depressive-like behavior.

     

    Diabetes

    Tualang Honey possesses characteristics of most of the currently prescribed antidiabetic drugs and suggests it is a novel antidiabetic agent. Consumption of honey or its addition to other carbohydrate diets is highly encouraged in diabetic patients. Glibenclamide and Metformin, the two most commonly prescribed antidiabetic drugs, combined with Tualang Honey improves glycemic control and other metabolic abnormalities.

    Tualang Honey and Kelulut Honey were found to have an anti-diabetic effect in three animal studies and two human studies.  

     

    Depression

    The elevated free-radical scavenging and antioxidant activity observed in Tualang Honey is due to the increased level of phenolic compounds. In addition to its antibacterial, anticarcinogenic, and anti-inflammatory properties, this study highlights the favorable antioxidant properties of Tualang Honey, which may be important to human nutrition and health. 

    Herein reports the possible neurological mechanisms of Tualang Honey, pertaining to its antioxidant and anti-inflammatory properties. These findings could aid in the development of new therapeutic roles for Tualang honey, such as in multiple sclerosis, amylotropic lateral sclerosis, and Parkinson’s disease, as well as in determining how to get the most out of this brain supplement. In order to develop this new prospective quality standard, more research is needed to describe Tualang honey’s bioactive chemicals, molecular mechanisms, and critical components that affect nootropic action. Furthermore, proper apicultural techniques should be promoted, particularly in regions rich in tropical rain forests.

     

    Kidney Disease

    Tualang Honey exhibits some degree of renoprotective effect biochemically in subjects fed with high cholesterol diet. 

     

    Lung Cancer 

    Gelam honey was reported to exhibit anti-oxidative, anti-tumour and anti-inflammatory properties against many types of cancer. The main aim of the present study was to evaluate the effect of Gelam honey on the oxidative stress level of human lung cancer cells. Gelam honey reduces lipid peroxidation but not protein oxidation in human lung cancer cells subjected to oxidative stress.

     

    Obesity

    Daily consumption for 14 days of Gelam Honey may have positive effects on body weight, meal pattern and biochemical parameters of consumers. Wild harvesting honey (Gelam Honey) exhibit more potential effects compared to beekeeping honey (like the kind found in grocery stores) in term of controlling weight gain and cholesterol level.  

    Tualang Honey, Gelam Honey, and Kelulut Honey share these major health benefits; (a) anti-oxidative; (b) anti-cancer; (c) anti-inflammatory; (d) wound-healing; (e) anti-microbial; (f) anti-diabetic; (g) anti-obesity; and favorable effects on the cardiovascular system, nervous system and reproductive system. 

    Kelulut Honey  has stronger antioxidant properties compared to other honey types and may be a functional food against Metabolic Syndrome (a group of conditions including central obesity, hyperglycemia, dyslipidemia, and hypertension that increases the risk for cardiometabolic diseases) induced by a High-Carbohydrate High-Fat diet. 

    Kelulut Honey Stingless bee honey, is a novel source of trehalulose: a biologically active disaccharide with health benefits. Trehalose has a number of potential health benefits, including: Helps stabilize blood sugar levels, Improves digestion, Boost immunity, Maintain a healthy weight, as it is a low-calorie sugar, Reduce inflammation, Prevents muscle deterioration, Provide energy, Promotes autophagy (cleaning of the cells),
    And more. 

     

    Osteoporosis

    Tualang Honey has the potential to be used as an alternative treatment for postmenopausal osteoporosis due to its anti-oxidative and anti-inflammatory properties against bone loss. As Tualang Honey was able to produce results as effective as Hormone Replacement Therapy (HRT), it can be used as an alternative in order to prevent bone loss with minimal side effects. Risks of hormone therapy include: heart disease, stroke, blood clots, and breast cancer.

    Oxidative stress induced by oestrogen deficiency is postulated as one of the mechanisms leading to postmenopausal osteoporosis. The effects of oestrogen-progestin therapy and Tualang Honey in postmenopausal women were compared. Tualang Honey supplementation for 16 weeks in postmenopausal women resulted in reduced oxidative stress as indicated by an increase in GPX or CAT activities and a decrease in 4-hydroxynonenal (4-HNE) level, respectively, at an extent comparable to those who received oestrogen-progestin therapy. This oestrogenic property of Tualang Honey could protect against postmenopausal osteoporosis.

    Tualang Honey was shown to have beneficial effects on menopausal rats by preventing uterine atrophy, increased bone density and suppression of increased body weight. Honey could be an alternative to HRT.

     

    Organ Failure

    Gelam Honey protects organs from lethal doses of Lipopolysaccharide (LPS) - the major component of the outer membrane of Gram-negative bacteria - by improving organ functions, reducing infiltration by Polymorphonuclear neutrophils (PMNs)  - immune cells that act as the first defense against infections - that cause tissue damage, reducing Myeloperoxidase (MPO) - a biomarker of Inflammation - activity and increasing the survival rate.

     

    Post-Menopause

    In a randomized, double-blind, two-armed parallel study on postmenopausal women, the group taking 20 grams (< 1/16 tsp) a day of Tualang Honey experienced a significant decrease in their diastolic blood pressure and fasting blood sugar.

    20 mg (< 1/16 tsp) a day of Tualang Honey in postmenopausal women led to an improvement in immediate memory, and performance was comparable to receiving estrogen and progestin therapy.

    Tualang Honey has the potential to be used as an alternative treatment for postmenopausal osteoporosis due to its anti-oxidative and anti-inflammatory properties against bone loss. As Tualang Honey was able to produce results as effective as Hormone Replacement Therapy (HRT), it can be used as an alternative in order to prevent bone loss with minimal side effects. Risks of hormone therapy include: heart disease, stroke, blood clots, and breast cancer. 

    Oxidative stress induced by oestrogen deficiency is postulated as one of the mechanisms leading to postmenopausal osteoporosis. The effects of oestrogen-progestin therapy and Tualang Honey in postmenopausal women were compared. Tualang Honey supplementation for 16 weeks in postmenopausal women resulted in reduced oxidative stress as indicated by an increase in GPX or CAT activities and a decrease in 4-hydroxynonenal (4-HNE) level, respectively, at an extent comparable to those who received oestrogen-progestin therapy. This oestrogenic property of Tualang Honey could protect against postmenopausal osteoporosis.

     

    Skin Cancer

    Honey can help treat skin cancer and other cancers. Several studies showed positive results of using honey on cancer cells. They mostly focused on honey’s ability to help slow the growth and reproduction of cancerous cells in the body.

    Honey helps with cancer treatments. Honey has antiproliferative, anticancer, and antimetastatic effects.

     

    Wounds

    Tualang Honey has antimicrobial, anti-inflammatory, antioxidant, antimutagenic, antitumor, and antidiabetic properties, in addition to wound-healing attributes. Some of Tualang Honey's properties are similar to the well-researched Manuka Honey (New Zealand and/or Australian monofloral honey). Distinct differences include Tualang Honey having higher phenolics, flavonoids, and 5-(hydroxymethyl) furfural (HMF). Compared with Manuka honey, Tualang Honey is also more effective against some gram-negative bacterial strains in burn wounds.

    Tualang Honey impregnated dressings were as effective as silver impregnated hydrofibre dressings in terms of dressing properties, promotion of wound healing and inflammatory reaction.

    Topical application of Gelam Honey and oral Gelam Honey administration significantly accelerates the rate of dermal repair in wound healing and significantly stimulates wound contraction, providing protection to the wound from further injuries and decreasing scar deposition. 

    Gelam-Honey-Dressed Wounds healed earlier than untreated and saline treated groups, as did wounds treated with Intrasite Gel. Gelam-Honey-Treated Wounds exhibited less scab and only thin scar formations. Histological features demonstrated positive effects of Gelam Honey on the wounds. This paper showed that Gelam Honey dressing on excisional wound accelerated the process of wound healing.

    Kelulut Honey has shown the strongest antibacterial activity among the Malaysian Honeys (more than Tualang Honey and Acacia) and can be considered as one of the alternative treatments to reduce the healing period of infected wound. Kelulut Honey has a close similarity to medical-grade Manuka.  

    Several studies on stingless bee honey like Kelulut Honey point out the numerous therapeutic profiles of this honey in terms of its antioxidant, antimicrobial, anti-inflammatory, as well as moisturizing properties are reviewed. All of these therapeutic properties are related to wound healing properties.

     

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